Centrosomal protein55 enhances melanoma cell proliferation, invasion and migration through PI3K/AKT signaling

Purpose: To investigate the role of centrosomal protein55 (CEP55) in melanoma. 
 Methods: The CEP55 expression human melanoma cells and normal melanocytes were determined by quantitative reverse transcription-polymerase chain reaction (qRT-PCR) western blot. Cell proliferation was evaluated colony formation CCK8 assays, while cell cycle assessed flow cytometry. Transwell assay used to migration invasion. Results: protein higher A-2058 A375 than HEMn-LP cells. Overexpression increased viability number colonies (p < 0.01), silencing reduced proliferation. promoted 0.01) via decreased p21 expression, but CyclinD1 CDK1 expression. Knockdown enhanced induce arrest. suppressed invasion downregulating p-AKT p-PI3K. Conclusion: Centrosomal functions as an oncogene activating PI3K/AKT signaling. Therefore, might be a promising target for diagnosis treatment.